Emerging applications of extracellular vesicles in tumor therapy

Cancer Nanotechnology

Review

Jing Jin¹  Junrong Zou²  Jiajia Jin³  Fei Zeng⁴  Shangzhi Feng⁵  Hui Luo⁵  Kecheng Lou⁵  Hailan He⁵ 

[1] Department of Gynecology, Dongyang Maternal and Child Health Hospital, Jinhua, Zhejiang, China;Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;Dongyang Weishan Town Central Health Hospital, Jinhua, Zhejiang, China;The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China;The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China;Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;

关键词: Extracellular vesicles;    Exosomes;    Nanotechnology;    Drug delivery;    Tumor therapy;   

DOI  :  10.1186/s12645-023-00217-3

 received in 2023-03-22, accepted in 2023-06-02,  发布年份 2023

来源: Springer

【 摘 要 】

Extracellular vesicles (EVs) have tremendous potential as nano/micron-sized drug delivery carriers. Their physical, chemical and biological characteristics distinguish them as unique carriers with specific pharmacokinetic, circulating metabolic, and biodistribution patterns in the delivery of therapeutic cargoes. They are critical mediators in the pathology of many diseases, including inflammatory diseases, fibrosis, and cancer, but they are also essential mediators in immunomodulation, cancer treatment, infectious defense, and tissue repair. In this review, we emphasize recent advances in oncology therapy using macrophage EVs, mesenchymal stem cell EVs, milk EVs, and plant EVs, as well as the advantages of EVs as delivery platforms and their prospective clinical applications and use.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 7