Systematic review of targeted extracellular vesicles for drug delivery - Considerations on methodological and biological heterogeneity

JOURNAL OF CONTROLLED RELEASE

卷:306

Review

Gudbergsson, Johann Mar¹  Jonsson, Katrine²  Simonsen, Jens Baek²  Johnsen, Kasper Bendix² 

[1] Aalborg Univ, Inst Hlth Sci & Technol, Lab Canc Biol, Fredrik Bajers Vej 3B, DK-9220 Aalborg, Denmark

[2] Tech Univ Denmark, Ctr Nanomed & Theranost, Dept Hlth Technol, Orsteds Plads 345C, DK-2800 Lyngby, Denmark

关键词: Extracellular vesicles;    Exosomes;    Microvesicles;    Drug delivery;    Liposomes;    Nanoparticles;    Pharmacokinetics;    Kinetics;    Treatment;   

DOI  :  10.1016/j.jconrel.2019.06.006

来源: Elsevier

【 摘 要 】

The idea of using extracellular vesicles (EVs) for targeted drug delivery was first introduced in 2011 and has since then gained increasing attention as promising new candidates in the field. Targeting EVs to areas of disease can be achieved through a complex process of designing and inserting a targeting ligand to the surface of the EVs. Although this can be obtained via chemical conjugation, the most important strategy has been to transfect or modulate the EV-producing cell to endow the EVs with the desired targeting capabilities. However, since EVs are harvested from biological sources, their composition is highly heterogeneous, which makes it difficult to control the purity and quality of the resulting EV-based drug delivery vehicles. In this review, we present a detailed account of EVs in targeted drug delivery based on a systematic literature search. We discuss the potential advantages of EVs compared to synthetic lipid-based nanocarriers, and the methodological and biological limitations associated with their use as targeted drug delivery vehicles.

【 授权许可】

Free