Functional proteins of mesenchymal stem cell-derived extracellular vesicles

Stem Cell Research & Therapy

Guoping Zheng¹  Menghua Ge¹  Jianguo Xu¹  Guanguan Qiu¹  Jiangmei Wang²  Ruoqiong Huang²  Qiang Shu² 

[1] Shaoxing Second Hospital;The Children’s Hospital of Zhejiang University School of Medicine;

关键词: Mesenchymal stem/stromal cells;    Extracellular vesicles;    Exosomes;    Microvesicles;    Functional proteins;   

DOI  :  10.1186/s13287-019-1484-6

来源: DOAJ

【 摘 要 】

Abstract Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine factors and MSC-derived EVs (MSC-EVs). Recent studies suggest that MSC-EVs may serve as a novel and cell-free alternative to whole-cell therapies. The focus of this review is to discuss the functional proteins which facilitate the effects of MSC-EVs. The first section of the review discusses the general functions of EV proteins. Next, we describe the proteomics of MSC-EVs as compared with their parental cells. Then, the review presents the current knowledge that protein contents of MSC-EVs play an essential role in immunomodulation and treatment of various diseases. In summary, functional protein components are at least partially responsible for disease-modulating capacity of MSC-EVs.

【 授权许可】

Unknown