Drug delivery into microneedle-porated nails from nanoparticle reservoirs

JOURNAL OF CONTROLLED RELEASE

卷:220

Article

Chiu, Wing Sin¹  Belsey, Natalie A.¹  Garrett, Natalie L.²  Moger, Julian²  Price, Gareth J.³  Delgado-Charro, M. Begona¹  Guy, Richard H.¹ 

[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

[2] Univ Exeter, Dept Phys & Med Imaging, Exeter EX4 4QL, Devon, England

[3] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

关键词: Nail;    Nanoparticles;    Microneedle poration;    Drug delivery;    Stimulated Raman scattering;   

DOI  :  10.1016/j.jconrel.2015.10.026

来源: Elsevier

【 摘 要 】

This study demonstrates the potential of polymeric nanoparticles as drug reservoirs for sustained topical drug delivery into microneedle-treated human nail. Laser scanning confocal microscopy was used to image the delivery of a fluorescent model compound from nanoparticles into the nail. A label-free imaging technique, stimulated Raman scattering microscopy, was applied, in conjunction with two-photon fluorescence imaging, to probe the disposition of nanoparticles and an associated lipophilic 'active' in a microneedle-porated nail. The results provide clear evidence that the nanoparticles function as immobile reservoirs, sequestered on the nail surface and in the microneedle-generated pores, from which the active payload can be released and diffuse laterally into the nail over an extended period of time. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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