Drug delivery applications of poly-γ-glutamic acid

Future Journal of Pharmaceutical Sciences

Olubusola A. Odeniyi¹  Olalekan A. Balogun-Agbaje²  Michael A. Odeniyi² 

[1] Department of Microbiology, University of Ibadan;Department of Pharmaceutics & Industrial Pharmacy, University of Ibadan;

关键词: Poly-γ-glutamic acid;    Medium optimization;    Nanoparticles;    Drug delivery;   

DOI  :  10.1186/s43094-021-00280-w

来源: DOAJ

【 摘 要 】

Abstract Background Poly-γ-glutamic acid (γ-PGA) is a biopolymer of microbial origin, consisting of repeating units of l-glutamic acid and/or D-glutamic acid. The biopolymer has found use in the fields of agriculture, food, wastewater, and medicine, owing to its non-toxic, biodegradable, and biocompatible properties. Due to its biodegradability, γ-PGA is being tipped to dislodge synthetic plastics in drug delivery application. High cost of production, relative to plastics, is however a clog in the wheel of achieving this. Main body of abstract This review looked at the production, nanoparticles fabrication, and drug delivery application of γ-PGA. γ-PGA production optimization by modifying the fermentation medium to tailor towards the production of desirable polymer at reduced cost and techniques for the formulation of γ-PGA nanoparticle as well as its characterization were discussed. This review also evaluated the application of γ-PGA and its nanoparticles in the delivery of drugs to action site. Characterization of γ-PGA and its nanoparticles is a crucial step towards determining the applicability of the biopolymer. γ-PGA has been used in the delivery of active agents to action sites. Conclusion This review highlights some of the efforts that have been made in the appraisal of γ-PGA and its nanoparticles for drug delivery. γ-PGA is a candidate for future extensive use in drug delivery.

【 授权许可】

Unknown