Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges

JOURNAL OF CONTROLLED RELEASE

卷:332

Review

Seoane-Viano, Iria^1,2  Januskaite, Patricija³  Alvarez-Lorenzo, Carmen⁴  Basit, Abdul W.^3,5  Goyanes, Alvaro^3,4,5 

[1] Univ Santiago de Compostela USC, Fac Pharm, Pharm & Pharmaceut Technol Paraquasil Grp, Dept Pharmacol, Santiago De Compostela 15782, Spain

[2] Hlth Res Inst Santiago de Compostela IDIS, Santiago De Compostela 15782, Spain

[3] UCL, UCL Sch Pharm, Dept Pharmaceut, 29-39 Brunswick Sq, London WC1N 1AX, England

[4] Univ Santiago de Compostela, Dept Farmacol Farm & Tecnol Farmaceut, I D Farma Grp GI 1645, Santiago De Compostela 15782, Spain

[5] FabRx Ltd, 3 Romney Rd, Ashford TN24 0RW, Kent, England

关键词: 3D printing;    Micro-extrusion;    Direct ink writing;    Personalized pharmaceuticals and medicines;    3D printed drug products and microneedles;    Rheology and food printing;   

DOI  :  10.1016/j.jconrel.2021.02.027

来源: Elsevier

【 摘 要 】

Three-dimensional (3D) printing is an innovative additive manufacturing technology, capable of fabricating unique structures in a layer-by-layer manner. Semi-solid extrusion (SSE) is a subset of material extrusion 3D printing, and through the sequential deposition of layers of gel or paste creates objects of any desired size and shape. In comparison to other extrusion-based technologies, SSE 3D printing employs low printing temperatures which makes it suitable for drug delivery and biomedical applications, and the use of disposable syringes provides benefits in meeting critical quality requirements for pharmaceutical use. Besides pharmaceutical manufacturing, SSE 3D printing has attracted increasing attention in the field of bioelectronics, particularly in the manufacture of biosensors capable of measuring physiological parameters or as a means to trigger drug release from medical devices. This review begins by highlighting the major printing process parameters and material properties that influence the feasibility of transforming a 3D design into a 3D object, and follows with a discussion on the current SSE 3D printing developments and their applications in the fields of pharmaceutics, bioprinting and bioelectronics. Finally, the advantages and limitations of this technology are explored, before focusing on its potential clinical applications and suitability for preparing personalised medicines.

【 授权许可】

Free