19F-nanoparticles: Platform for in vivo delivery of fluorinated biomaterials for 19F-MRI

JOURNAL OF CONTROLLED RELEASE

卷:338

Article

Mali, Alvja¹  Kaijzel, Eric L.¹  Lamb, Hildo J.²  Cruz, Luis J.¹ 

[1] Leiden Univ, Dept Radiol, Translat Nanobiomat & Imaging TNI Grp, Med Ctr LUMC, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

[2] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands

关键词: Fluorine-19;    F-19 magnetic resonance imaging;    Perfluocarbons;    Nanoparticles;    Nanoprobes;   

DOI  :  10.1016/j.jconrel.2021.09.001

来源: Elsevier

【 摘 要 】

Fluorine-19 (F-19) magnetic resonance imaging (MRI) features one of the most investigated and innovative techniques for quantitative and unambiguous cell tracking, providing information for both localization and number of cells. Because of the relative insensitivity of the MRI technique, a high number of magnetically equivalent fluorine atoms are required to gain detectable signals. However, an increased amount of F-19 nuclei induces low solubility in aqueous solutions, making fluorine-based probes not suitable for in vivo imaging applications. In this context, nanoparticle-based platforms play a crucial role, since nanoparticles may carry a high payload of F-19-based contrast agents into the relevant cells or tissues, increase the imaging agents biocompatibility, and provide a highly versatile platform. In this review, we present an overview of the F-19-based nanoprobes for sensitive F-19-MRI, focusing on the main nanotechnologies employed to date, such as fluorine and theranostic nanovectors, including their design and applications.

【 授权许可】

Free