Nanoparticle-mediated approaches for Alzheimer's disease pathogenesis, diagnosis, and therapeutics

JOURNAL OF CONTROLLED RELEASE

卷:314

Review

Hettiarachchi, Sajini D.¹  Zhou, Yiqun¹  Seven, Elif¹  Lakshmana, Madepalli K.²  Kaushik, Ajeet K.³  Chand, Hitendra S.²  Leblanc, Roger M.¹ 

[1] Univ Miami, Dept Chem, 1301 Mem Dr, Coral Gables, FL 33146 USA

[2] Florida Int Univ, Herbert Wertheim Coll Med, Dept Immunol & Nanomed, 11200 SW 8th St, Miami, FL 33199 USA

[3] Florida Polytech Univ, Div Sci Arts & Math, Dept Nat Sci, Lakeland, FL 33805 USA

关键词: Alzheimer's disease;    Nanoparticles;    Amyloid beta;    Acetylcholine;    ROS;    Tau protein;   

DOI  :  10.1016/j.jconrel.2019.10.034

来源: Elsevier

【 摘 要 】

Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder manifested by memory loss and cognitive impairment. Deposition of the amyloid beta plaques has been identified as the most common AD pathology; however, the excessive accumulation of phosphorylated or total tau proteins, reactive oxygen species, and higher acetylcholinesterase activity are also strongly associated with Alzheimer's dementia. Several therapeutic approaches targeting these pathogenic mechanisms have failed in clinical or preclinical trials, partly due to the limited bioavailability, poor cell, and blood-brain barrier penetration, and low drug half-life of current regimens. The nanoparticles (NPs)-mediated drug delivery systems improve drug solubility and bioavailability, thus renders as superior alternatives. Moreover, NPs-mediated approaches facilitate multiple drug loading and targeted drug delivery, thereby increasing drug efficacy. However, certain NPs can cause acute toxicity damaging cellular and tissue architecture, therefore, NP material should be carefully selected. In this review, we summarize the recent NPs-mediated studies that exploit various pathologic mechanisms of AD by labeling, identifying, and treating the affected brain pathologies. The disadvantages of the select NP-based deliveries and the future aspects will also be discussed.

【 授权许可】

Free