Nanoparticle-hydrogel superstructures for biomedical applications

JOURNAL OF CONTROLLED RELEASE

卷:324

Article

Jiang, Yao¹  Krishnan, Nishta¹  Heo, Jiyoung¹  Fang, Ronnie H.¹  Zhang, Liangfang¹ 

[1] Univ Calif San Diego, Moores Canc Ctr, Chem Engn Program, Dept NanoEngn, La Jolla, CA 92093 USA

关键词: Nanomedicine;    Nanoparticle;    Hydrogel hybrid;    Drug delivery;    Detoxification;    Immune modulation;    Tissue engineering;   

DOI  :  10.1016/j.jconrel.2020.05.041

来源: Elsevier

【 摘 要 】

The incorporation of nanoparticles into hydrogels yields novel superstructures that have become increasingly popular in biomedical research. Each component of these nanoparticle-hydrogel superstructures can be easily modified, resulting in platforms that are highly tunable and inherently multifunctional. The advantages of the nanoparticle and hydrogel constituents can be synergistically combined, enabling these superstructures to excel in scenarios where employing each component separately may have suboptimal outcomes. In this review, the synthesis and fabrication of different nanoparticle-hydrogel superstructures are discussed, followed by an overview of their use in a range of applications, including drug delivery, detoxification, immune modulation, and tissue engineering. Overall, these platforms hold significant clinical potential, and it is envisioned that future development along these lines will lead to unique solutions for addressing areas of pressing medical need.

【 授权许可】

Free