Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

Nano-Micro Letters

Jiang Peng¹  Quanyi Guo¹  Xu Li²  Jiaxin Guo²  Ling Qin²  Bingyang Dai²  Lizhen Zheng²  Jiankun Xu² 

[1] Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Institute of Orthopedics, Chinese PLA General Hospital, Beijing, People’s Republic of China;Musculoskeletal Research Laboratory, Department of Orthopedics and Traumatology, The Chinese University of Hong Kong, Sha Tin, Hong Kong, SAR, People’s Republic of China;Joint Laboratory of Chinese Academic of Science and Hong Kong for Biomaterials, The Chinese University of Hong Kong, Sha Tin, Hong Kong, SAR, People’s Republic of China;Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Sha Tin, Hong Kong, SAR, People’s Republic of China;

关键词: Nanoparticle;    Drug delivery;    Osteoarthritis;    Articular cartilage;    Nanomedicine;   

DOI  :  10.1007/s40820-021-00670-y

来源: Springer

【 摘 要 】

tsNanoparticles hold considerable promise for controlling the local pharmacokinetics of therapeutic agents during osteoarthritis therapy.The advantages of nanoparticles, the bioactive design, the transports and interactions within cartilage, and therapeutic mechanisms are discussed.This review proposes future strategies to design more intelligent and multi-functional nanomaterials as delivery systems for cartilage therapy.

【 授权许可】

CC BY