Polymer particle shape independently influences binding and internalization by macrophages

JOURNAL OF CONTROLLED RELEASE

卷:147

Article

Sharma, Gaurav¹  Valenta, David T.¹  Altman, Yoav¹  Harvey, Sheryl¹  Xie, Hui¹  Mitragotri, Samir²  Smith, Jeffrey W.¹ 

[1] Sanford Burnham Med Res Inst, La Jolla, CA 92037 USA

[2] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA

关键词: Drug delivery;    Nanomedicine;    Macrophage;    Phagocytosis;    Nanoparticle;   

DOI  :  10.1016/j.jconrel.2010.07.116

来源: Elsevier

【 摘 要 】

The interaction of macrophages with micro and nanoparticles (MNPs) is important because these cells clear particles from the circulation, and because they are potential therapeutic targets in inflammatory conditions, atherosclerosis and cancer. Therefore, an understanding of the features of MNPs that influence their interaction with macrophages may allow optimization of their properties for enhanced drug delivery. In this study, we show that particle shape impacts phagocytosis by macrophages, and more importantly, that particle shape and size separately impact attachment and internalization. The study provides a methodology for further exploring how particle shape can be controlled to achieve desired attachment and internalization. The results of the study also give mechanistic guidance on how particle shape can be manipulated to design drug carriers to evade macrophages, or alternatively to target macrophages. (C) 2010 Elsevier B.V. All rights reserved.

【 授权许可】

Free