INHIBITION OF DIFFERENT DOSAGES OF OXATOMIDE OR PLACEBO ON SKIN PRICK TEST AND NASAL ALLERGEN PROVOCATION

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:88

Article

PIACENTINI, GL ; PERONI, DG ; SETTE, L ; BONIZZATO, C ; BENEDETTI, M ; BONER, AL

关键词: OXATOMIDE;    ANTIHISTAMINES;    CHILDREN;    RHINITIS;    PRICK TEST;    NASAL CHALLENGE;   

DOI  :  10.1016/0091-6749(91)90332-I

来源: Elsevier

【 摘 要 】

In this two-stage, double-blind study, we evaluated the effects of different dosages of oxatomide (1 and 2 mg/kg/day) on nasal provocation and skin reaction wheal induced by grass-pollen challenge. Children with a positive history of allergic rhinoconjunctivitis and positive responses to skin prick test and nasal provocation test to grass pollen were studied out of season. The results obtained with 1 mg/kg/day of oxatomide demonstrated no significant difference in wheal areas and nasal secretion induced by allergen challenge between treated and untreated patients. The administration of 2 mg/kg/day demonstrated a significant suppression in wheal reaction and nasal secretion induced by specific challenge.

【 授权许可】

Free