ANTIALLERGIC PROPERTIES OF THE 2ND-GENERATION H1-ANTIHISTAMINES DURING THE EARLY AND LATE REACTIONS TO ANTIGEN

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:90

Article

关键词: ANTIGEN CHALLENGE;    ANTIHISTAMINES;    PLATELET-ACTIVATING FACTOR;    ASTHMA;    BRONCHOCONSTRICTION;    AZELASTINE;    CETIRIZINE;    KETOTIFEN;    TERFENADINE;   

DOI  :  10.1016/0091-6749(92)90158-X

来源: Elsevier

【 摘 要 】

Some of the second-generation H-1 antihistamines reduce the bronchoconstrictor response after exercise and antigen challenge. For example, terfenadine causes a slight but significant increase in forced expiratory volume after 1 second. At doses of 120 and 240 mg, terfenadine has a protective effect against asthma induced by ultrasonic nebulized distilled water and cold air hyperventilation challenge. Certain other newer antihistamines, such as ketotifen, azelastine, and cetirizine, have additional antiallergy properties. These effects include inhibition of eosinophil, basophil, and neutrophil migration and platelet-activating factor-induced eosinophil accumulation in skin. The ability of cetirizine (and perhaps other antihistamines) to inhibit these responses al usual therapeutic doses may be useful in investigating the late allergic reaction.

【 授权许可】

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