The who, where, and when of IgE in allergic airway disease

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:129

Article

Dullaers, Melissa¹  De Bruyne, Ruth²  Ramadani, Faruk^3,4,5  Gould, Hannah J.^3,4,5  Gevaert, Philippe⁶  Lambrecht, Bart N.¹ 

[1] Univ Hosp Ghent, Lab Immunoregulat & Mucosal Immunol, Dept Pulm Med, Ghent, Belgium

[2] Univ Hosp Ghent, Dept Paediat Gastroenterol & Hepatol, Ghent, Belgium

[3] Kings Coll London, Randall Div Cell & Mol Biophys, London, England

[4] Kings Coll London, MRC, London, England

[5] Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London, England

[6] Univ Ghent, Upper Airways Res Lab, Dept Otorhinolaryngol, Ghent, Belgium

关键词: IgE;    atopic asthma;    allergic rhinitis;    memory B cells;    plasma cells;   

DOI  :  10.1016/j.jaci.2011.10.029

来源: Elsevier

【 摘 要 】

Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a T(H)2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention. However, our understanding of IgE biology remains fragmentary. This article puts together our current knowledge on IgE in allergic airway diseases with a special focus on the identity of IgE-secreting cells (who''), their location (where''), and the circumstances in which they are induced (when''). We further consider the therapeutic implications of the insights gained. (J Allergy Clin Immunol 2012; 129: 635-45.)

【 授权许可】

Free