Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:119

Article

Taylor, Angie L. ; Dunstan, Janet A. ; Prescott, Susan L.

关键词: probiotic;    infant;    atopic dermatitis;    sensitization;    allergy prevention;   

DOI  :  10.1016/j.jaci.2006.08.036

来源: Elsevier

【 摘 要 】

Background: Despite preliminary evidence, the role of probiotics in allergy prevention is unclear. Objective: To determine whether early probiotic supplementation prevents allergic disease in high-risk infants. Methods: Newborns of women with allergy (n = 231) received either Lactobacillus acidophilus (LAVRI-A1) or placebo daily for the first 6 months of life. Children were assessed for atopic dermatitis (AD) and other symptoms at 6 and 12 months and had allergen skin prick tests (SPT) at 12 months of age. Results: A total of 178 infants completed the supplementation period. Those in the probiotic group showed significantly higher rates of Lactobacillus colonization (P =.039). At 6 months, AD rates were similar in the probiotic (n 23/89; 25.8%) and placebo (n = 20/88; 22.7%) groups (P.629). There was also no difference at 12 months, although the proportion of children with SPT+AD was significantly higher in the probiotic group (P =.045). At 12 months, the rate of sensitization was significantly higher in the probiotic group (P =.030). The presence of culturable Lactobacilli or Bifidobacterium in stools in the first month of life was not associated with the risk of subsequent sensitization or disease; however, the presence of Lactohacillus at 6 months of age was associated with increased risk of subsequent cow's milk sensitization (P =.012). Conclusion: Early probiotic supplementation with L acidophilus did not reduce the risk of AD in high-risk infants and was associated with increased allergen sensitization in infants receiving supplements. The long-term significance of the increased rate of sensitization needs to be investigated in further studies. Clinical implications: These findings challenge the role of probiotics in allergy prevention.

【 授权许可】

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