Anti-cockroach and anti-mouse IgE are associated with early wheeze and atopy in an inner-city birth cohort

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:122

Article

Donohue, Kathleen M.¹  Al-alem, Umaima⁵  Perzanowski, Matthew S.^2,3  Chew, Ginger L.^2,3  Johnson, Alina^1,2  Divjan, Adnan^2,3  Kelvin, Elizabeth A.⁴  Hoepner, Lori A.^2,3  Perera, Frederica P.^2,3  Miller, Rachel L.^1,2,3 

[1] Columbia Univ Coll Phys & Surg, Dept Med, Div Pulm Allergy & Crit Care Med, New York, NY 10032 USA

[2] Columbia Univ, CCCEH, New York, NY USA

[3] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA

[4] New York State Psychiat Inst & Hosp, Data Coordinating Ctr, New York, NY 10032 USA

[5] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL USA

关键词: Cockroach;    mouse;    allergy;    wheeze;    inner city;    rhinitis;    IgE;    atopic dermatitis;    eczema;    asthma;    sensitization;   

DOI  :  10.1016/j.jaci.2008.08.034

来源: Elsevier

【 摘 要 】

Background: The relationships between cockroach and mouse allergen exposure, anti-cockroach and anti-mouse IgE, and wheeze, rhinitis, and atopic dermatitis in children as young as age 3 years are of public health importance but have not been thoroughly evaluated. Objective: We hypothesized that inner-city children might have anti-cockroach and anti-mouse IgE by age 3 years, and their presence would be associated with respiratory and atopic symptoms. Methods: Children were followed prospectively from birth through age 3 years (n = 404). Residential levels of cockroach and mouse allergens, sera levels of anti-cockroach and anti-mouse IgE, and parental report of wheeze, rhinitis, and atopic dermatitis were measured. Results: The odds of early wheeze were significantly higher among children who had IgE to cockroach (odds ratio [OR], 3.3; 95% Cl, 1.8-6.2), mouse (OR, 4.6; 95% Cl, 2.3-9.0), or both (OR, 9.7; 95% Cl, 3.4-27.3). The odds or rhinitis or atopic dermatitis were also higher among children with IgE to cockroach, mouse, or both. Higher IgE class to cockroach and mouse was associated with wheeze and atopic dermatitis (tests for trend, P<.002). Conclusions: Children age 2 to 3 years who have anti-cockroach and anti-mouse IgE are at increased risk of wheeze and atopy. Moreover, a dose-response relationship was found between higher IgE class and increased prevalence of wheeze, rhinitis, or atopic dermatitis. These findings indicate the importance of reducing exposure to cockroach and mouse allergens for susceptible children. (J Allergy Clin Immunol 2008;122: 914-20.)

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