Advances in atopic dermatitis in 2015

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:138

Article

Nomura, Takashi^1,2  Kabashima, Kenji^1,3,4,5 

[1] Kyoto Univ, Grad Sch Med, Dept Dermatol, Kyoto, Japan

[2] Kyoto Univ Hosp, Inst Adv Clin & Translat Sci iACT, Dept Expt Therapeut, Kyoto, Japan

[3] ASTAR, Biopolis, Singapore Immunol Network SIgN, Singapore, Singapore

[4] ASTAR, Biopolis, Inst Med Biol, Singapore, Singapore

[5] Japan Sci & Technol Agcy, PRESTO, Saitama, Japan

关键词: Atopic dermatitis;    filaggrin;    biologics;    cytokines;    chemokines;    thymic stromal lymphopoietin;    chemoattractant receptor-homologous molecule expressed on T(H)2 cells;    petrolatum;    ultraviolet B;    sirtuin 1;    aryl hydrocarbon receptor;    Janus kinase;    signal transducer and activator of transcription 3;    extracellular;    signal-regulated kinase;    pathogenic effector T(H)2 T(H)1T(H)2 T(H)17 T(H)22;    transepidermal water loss;    adiposity;    JTE-052;   

DOI  :  10.1016/j.jaci.2016.10.004

来源: Elsevier

【 摘 要 】

This review aims to highlight recently published articles on atopic dermatitis (AD). Updated are the insights into epidemiology, pathology, diagnostics, and therapy. Epidemiologic studies have revealed a positive correlation between AD and systemic conditions, such as rheumatoid arthritis, inflammatory bowel disease, and neonatal adiposity. Pathologic findings highlight the involvement of novel barrier factors (desmoplakin and claudin), novel immune cell subsets (pathogenic effector T(H)2 cells and group 2 innate lymphoid cells), and differential skewing of helper T cells (eg, T(H)17 dominance in Asians with AD). As diagnostics, noninvasive examinations of the transepidermal water loss of neonates, the density of epidermal Staphylococcus species, and the gut flora might prognosticate the onset of AD. As for therapy, various methods are proposed, including conventional (petrolatum and UV) and molecule-oriented regimens targeting Janus kinase, signal transducer and activator of transcription 3, extracellular signal-regulated kinase, sirtuin 1, or aryl hydrocarbon receptor.

【 授权许可】

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