EFFECT OF DIETARY FISH OIL SUPPLEMENTATION ON THE ANTIGEN-INDUCED LATE-PHASE RESPONSE IN THE SKIN

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:89

Article

THIEN, FCK ; ATKINSON, BA ; KHAN, A ; MENCIAHUERTA, JM ; LEE, TH

关键词: ALLERGENS;    LATE-PHASE RESPONSE;    EICOSAPENTAENOIC ACID;    FISH OILS;    EOSINOPHILS;   

DOI  :  10.1016/0091-6749(92)90438-8

来源: Elsevier

【 摘 要 】

We have studied the effect of dietary fish oil supplementation (3.2 gm/day of eicosapentaenoic acid and 2.2 gm/day of docosahexaenoic acid) for 10 weeks on the antigen-induced, cutaneous late-phase response (LPR) in 16 atopic individuals. All subjects developed an LPR to intradermal allergen injection. The mean +/- SEM area of induration at 6 hours was 1840 +/- 472 mm2. A biopsy was performed at the LPR site at 6 hours. Subjects were then randomized to receive fish oil or placebo olive oil in a double-blind, parallel fashion, for 10 weeks. After the diet, there were no significant differences between fish oil and placebo treatment in the size of the immediate wheal-and-flare response or the extent of induration at 4 and 6 hours, as compared with prediet values in each group. Histologically, at 6 hours, there was a significant infiltrate into the allergen site compared with that of the control diluent site of total inflammatory cells (p < 0.002) as well as of eosinophils (p < 0.001). However, there were no significant differences when pre- and postdiet values were compared. Hence, we conclude that dietary fish oil supplementation does not inhibit the cutaneous LPR clinically or histologically.

【 授权许可】

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