Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:131

Article

Gittler, Julia K.^1,2  Krueger, James G.²  Guttman-Yassky, Emma^2,3 

[1] Albert Einstein Coll Med, Bronx, NY 10467 USA

[2] Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA

[3] Mt Sinai Sch Med, Dept Dermatol, New York, NY 10029 USA

关键词: Atopic dermatitis;    allergic contact dermatitis;    contact hypersensitivity;    irritant contact dermatitis;    epidermal barrier;    immune activation;    T(H)2;    T(H)17;   

DOI  :  10.1016/j.jaci.2012.06.048

来源: Elsevier

【 摘 要 】

Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD. (J Allergy Clin Immunol 2013;131:300-13.)

【 授权许可】

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