Innate signals in mucosal immunoglobulin class switching

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:126

Review

Cols, Montserrat²  Cerutti, Andrea^1,2 

[1] IMIM Hosp Mar, Catalan Inst Res & Adv Studies, Barcelona 08003, Spain

[2] Mt Sinai Sch Med, Dept Med, Inst Immunol, New York, NY USA

关键词: Mucosal immunity;    B cells;    immunoglobulin;    class switching;   

DOI  :  10.1016/j.jaci.2010.09.026

来源: Elsevier

【 摘 要 】

The intestinal mucosa contains large communities of commensal bacteria that process otherwise indigestible food components, synthesize essential vitamins, stimulate the maturation of the immune system, and form an ecologic niche that prevents the growth of pathogenic species. Conversely, the intestine provides the commensals with a stable habitat rich in energy derived from the ingested food. A delicate homeostatic balance maintains this mutualistic relationship without triggering a destructive inflammatory response. Commensals orchestrate intestinal homeostasis by entertaining an intimate dialogue with epithelial cells and immune cells lodged in the mucosa. Such a dialogue generates finely tuned signaling programs that ensure a state of hyporesponsiveness against noninvasive commensals and a state of active readiness against invasive pathogens. In this dialogue epithelial cells function as interpreters that continuously translate microbial messages to instruct immune cells as to the antigenic composition of the intestinal lumen. This education process initiates sophisticated defensive strategies that comprise massive production of IgA, a noninflammatory mucosal antibody class that generates immunity while preserving homeostasis. (J Allergy Clin Immunol 2010; 126:889-95.)

【 授权许可】

Free