Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:138

Article

Egawa, Gyohei¹  Kabashima, Kenji^1,2,3,4 

[1] Kyoto Univ, Grad Sch Med, Dept Dermatol, Kyoto, Japan

[2] ASTAR, Biopolis, Singapore Immunol Network SIgN, Singapore, Singapore

[3] ASTAR, Biopolis, Inst Med Biol, Singapore, Singapore

[4] Japan Sci & Technol Agcy, PRESTO, Saitama, Japan

关键词: Atopic dermatitis;    barrier function;    stratum corneum;    corneocytes;    cornified envelope;    tight junction;    filaggrin;    lipid;   

DOI  :  10.1016/j.jaci.2016.06.002

来源: Elsevier

【 摘 要 】

Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized world and has multiple causes. Over the past decade, data from both experimental models and patients have highlighted the primary pathogenic role of skin barrier deficiency in patients with AD. Increased access of environmental agents into the skin results in chronic inflammation and contributes to the systemic atopic (allergic) march.'' In addition, persistent skin inflammation further attenuates skin barrier function, resulting in a positive feedback loop between the skin epithelium and the immune system that drives pathology. Understanding the mechanisms of skin barrier maintenance is essential for improving management of AD and limiting downstream atopic manifestations. In this article we review the latest developments in our understanding of the pathomechanisms of skin barrier deficiency, with a particular focus on the formation of the stratum corneum, the outermost layer of the skin, which contributes significantly to skin barrier function.

【 授权许可】

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