Microstructure and antibacterial efficacy of graphene oxide nanocomposite fibres

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:571

Article

Matharu, Rupy Kaur^1,2  Tabish, Tanveer A.³  Trakoolwilaiwan, Thithawat¹  Mansfield, Jessica³  Moger, Julian³  Wu, Tongfei⁴  Lourenco, Claudio⁵  Chen, Biqiong⁶  Ciric, Lena²  Parkin, Ivan P.⁵  Edirisinghe, Mohan¹ 

[1] UCL, Dept Mech Engn, Torrington Pl, London WC1E 7JE, England

[2] UCL, Dept Civil Environm & Geomat Engn, London WC1E 7JE, England

[3] Univ Exeter, Sch Phys & Astron, North Pk Rd, Exeter EX4 4QL, Devon, England

[4] Univ Sheffield, Dept Mat Sci & Engn, Mappin St, Sheffield S1 3JD, S Yorkshire, England

[5] UCL, Dept Chem, Gordon St, London WC1H 0AJ, England

[6] Queens Univ Belfast, Sch Mech & Aerosp Engn, Stranmillis Rd, Belfast BT9 5AH, Antrim, North Ireland

关键词: Antibacterial;    Graphene oxide;    Nanocomposite;    Fibers;    Reactive oxygen species;    Raman scattering;    Nanosheets;   

DOI  :  10.1016/j.jcis.2020.03.037

来源: Elsevier

【 摘 要 】

Antibacterial polymer nanocomposite fibre meshes containing graphene oxide (GO) nanosheets were successfully prepared by pressurised gyration. The morphological and chemical composition of the resulting fibre meshes were determined using Scanning Electron Microscopy (SEM), Raman spectroscopy, Raman mapping and Fourier-Transform Infrared Spectroscopy (FT-IR). SEM showed the fibres to have an average diameter increasing from similar to 1-4 mu m as the GO loading increased. FT-IR and Raman spectroscopy confirmed the inclusion of GO nanosheets on the fibre surface. The antibacterial potential of GO nanocomposite fibres were investigated using Escherichia coli K12. Average bacterial reduction ranged from 46 to 85 % with results favouring the strongest bioactivities of the nanocomposite containing 8 wt% of GO. Finally, bacterial toxicity of the nanocomposites was evaluated by reactive oxygen species (ROS) formation. A mechanism for the antibacterial behaviour of the nanocomposite fibres is presented. Stimulated Raman scattering imaging and spectra of the fibres post antibacterial studies showed flakes of GO distributed across the surface of the poly(methyl 2-methylpropenoate) (PMMA) fibres, which contribute to the high killing efficacy of the composites towards E. coli. GO nanosheets embedded in a polymer matrix have demonstrated the ability to retain their antibacterial properties, thus offering themselves as a promising antibacterial agent. (C) 2020 Elsevier Inc. All rights reserved.

【 授权许可】

Free