iRGD-decorated red shift emissive carbon nanodots for tumor targeting fluorescence imaging

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:509

Article

Yang, Yuanyuan¹  Wang, Xuefeng²  Liao, Guochao³  Liu, Xiqiang^4,5  Chen, Qiling¹  Li, Hongmei¹  Lu, Ling¹  Zhao, Peng¹  Yu, Zhiqiang¹ 

[1] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China

[2] Southern Med Univ, Zhujiang Hosp, Dept Obstet & Gynecol, Guangzhou 510282, Guangdong, Peoples R China

[3] Guangzhou Univ Chinese Med, Int Inst Translat Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, Dept Oral & Maxillofacial Surg, Guanghua Sch, Guangzhou 510055, Guangdong, Peoples R China

[5] Sun Yat Sen Univ, Hosp Stomatol, Guangzhou 510055, Guangdong, Peoples R China

关键词: Carbon nanodots;    iRGD;    Tumor targeting;    Fluorescence imaging;    Deep penetration;   

DOI  :  10.1016/j.jcis.2017.09.007

来源: Elsevier

【 摘 要 】

Carbon nanodots (CDs) have been exhibiting increasing applications owing to their luminescence properties and biocompatibility as imaging probes in diagnosis. However, poor tumor targeting and penetration of CDs is still the biggest challenge limiting their tumor imaging efficacy. To improve the tumor targeting and penetration efficiency of CDs, we developed an active tumor targeting imaging system by simply fabricating a tumor-homing penetration peptide iRGD (CRGDKGPDC) to red shift emissive CDs (iRGD-CDs) with a physical method. Particularly, iRGD-CDs showed a small size and red shift fluorescence signals as CDs, which made iRGD-CDs suitable for in vivo fluorescence imaging. iRGD-CDs showed higher cellular uptake in vitro, while presented higher penetration and accumulation in tumor tissue in vivo, leading to better tumor imaging efficacy. In conclusion, decoration with iRGD could significantly increase the permeability of CDs in tumor vessels and tumor tissue, generating more CDs leaking out from tumor vasculature, consequently improving the sensitivity of tumor imaging. (C) 2017 Published by Elsevier Inc.

【 授权许可】

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