An iRGD Based Strategy to Study Electrochemically the Species Inside a Cell

International Journal of Molecular Sciences

Limin Ning²  Xiaoxi Li²  Xiaorong Ding³  Yongmei Yin¹ 

[1] Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; E-Mail:;Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China; E-Mails:;Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, China; E-Mail:

关键词: iRGD;    cell penetration;    doxorubicin;    cell adhesion;    electrochemistry;   

DOI  :  10.3390/ijms130810424

来源: mdpi

【 摘 要 】

This paper reports a method for electrical communication between the inner part of cells and an electrode with the help of iRGD peptide. Due to the enhancement of the cell penetration caused by iRGD peptide, DNA molecules, previously modified on a gold electrode surface, can be easily transfected into the cells. At the same time, doxorubicin, an anticancer drug, can also be transfected into cells with high penetration. Consequently, doxorubicin binds to DNA chains through electrostatic interaction, and the redox reaction is transferred out of the cell across the cell membrane. As a result, this work may provide a novel way to get information from inside of cells.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.