Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins

JOURNAL OF HEPATOLOGY

卷:58

Review

Walenbergh, Sofie M. A.¹  Koek, Ger H.²  Bieghs, Veerle¹  Shiri-Sverdlov, Ronit¹ 

[1] Maastricht Univ, Dept Mol Genet, NL-6200 MD Maastricht, Netherlands

[2] MUMC, Div Gastroenterol & Hepatol, Dept Internal Med, Maastricht, Netherlands

关键词: Liver;    Non-alcoholic steatohepatitis;    Inflammation;    Kupffer cells;    Cholesterol;    OxLDL;    Metabolic syndrome;   

DOI  :  10.1016/j.jhep.2012.11.014

来源: Elsevier

【 摘 要 】

Non-alcoholic steatohepatitis (NASH) is hallmarked by lipid accumulation in the liver (steatosis) along with inflammation (hepatitis). The transition from simple steatosis towards NASH represents a key step in pathogenesis, as it will set the stage for further severe liver damage. Yet, the pathogenesis behind hepatic inflammation is still poorly understood. It is of relevance to better understand the underlying mechanisms involved in NASH in order to apply new knowledge to potential novel therapeutic approaches. In the current review, we propose oxidized cholesterol as a novel risk factor for NASH. Here, we summarize mouse and human studies that provide possible mechanisms for the involvement of oxidized low-density lipoproteins in NASH and consequent potential novel diagnostic tools and treatment strategies for hepatic inflammation. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free