TNFα-Mediated Liver Destruction by Kupffer Cells and Ly6Chi Monocytes during Entamoeba histolytica Infection

PLoS Pathogens

Thomas Jacobs¹  Elena Helk¹  Egbert Tannich¹  Hannah Bernin¹  Hannelore Lotter¹  Harald Ittrich²  Thomas Ernst²  Joerg Heeren³  Frank Tacke⁴ 

[1] Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany;Department and Clinic for Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;Department of Medicine III, University Hospital Aachen, Aachen, Germany

关键词: Abscesses;    Monocytes;    Neutrophils;    Kupffer cells;    Macrophages;    Entamoeba histolytica;    Inflammation;    Trophozoites;   

DOI  :  10.1371/journal.ppat.1003096

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Amebic liver abscess (ALA) is a focal destruction of liver tissue due to infection by the protozoan parasite Entamoeba histolytica (E. histolytica). Host tissue damage is attributed mainly to parasite pathogenicity factors, but massive early accumulation of mononuclear cells, including neutrophils, inflammatory monocytes and macrophages, at the site of infection raises the question of whether these cells also contribute to tissue damage. Using highly selective depletion strategies and cell-specific knockout mice, the relative contribution of innate immune cell populations to liver destruction during amebic infection was investigated. Neutrophils were not required for amebic infection nor did they appear to be substantially involved in tissue damage. In contrast, Kupffer cells and inflammatory monocytes contributed substantially to liver destruction during ALA, and tissue damage was mediated primarily by TNFα. These data indicate that besides direct antiparasitic drugs, modulating innate immune responses may potentially be beneficial in limiting ALA pathogenesis.

【 授权许可】

CC BY