Release of particulate matter from nano-enabled building materials (NEBMs) across their lifecycle: Potential occupational health and safety implications

JOURNAL OF HAZARDOUS MATERIALS

卷:422

Article

Singh, Dilpreet¹  Marrocco, Antonella¹  Wohlleben, Wendel²  Park, Hae-Ryung³  Diwadkar, Avantika R.⁴  Himes, Blanca E.⁴  Lu, Quan⁵  Christiani, David C.¹  Demokritou, Philip¹ 

[1] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Ctr Nanotechnol & Nanotoxicol, 665 Huntington Ave, Boston, MA 02115 USA

[2] BASF SE Mat Phys, D-67056 Ludwigshafen, Germany

[3] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA

[4] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA

[5] Harvard Univ, TH Chan Sch Publ Hlth, Dept Environm Hlth, Mol & Integrat Physiol Sci, 665 Huntington Ave, Boston, MA 02115 USA

关键词: Nanofiller;    Engineered nanomaterials;    Coatings;    Insulations;    Sanding;    Incineration;    UV-aging/weathering;    Exposure and risk assessment;   

DOI  :  10.1016/j.jhazmat.2021.126771

来源: Elsevier

【 摘 要 】

The present study investigates potential nanomaterial releases and occupational health risks across the lifecycle of nano-enabled building materials (NEBMs), namely, insulations and coatings. We utilized real-world degradation scenarios of a) sanding (mechanical), b) incineration (thermal), and c) accelerated UV-aging (environmental) followed by incineration. Extensive physicochemical characterization of the released lifecycle particulate matter (LCPM) was performed. The LCPM2.5 aerosol size fraction was used to assess the acute biological, cytotoxic and inflammatory effects on Calu-3 human lung epithelial cells. RNA-Seq analysis of exposed cells was performed to assess potential for systemic disease. Findings indicated that release dynamics and characteristics of LCPM depended on both the NEBM composition and the degradation scenario(s). Incineration emitted a much higher nanoparticle number concentration than sanding (nearly 4 orders of magnitude), which did not change with prior UV-aging. Released nanofillers during sanding were largely part of the matrix fragments, whereas those during incineration were likely physicochemically transformed. The LCPM from incineration showed higher bioactivity and inflammogenicity compared to sanding or sequential UV-aging and incineration, and more so when metallic nanofillers were present (such as Fe2O3). Overall, the study highlights the need for considering real-world exposure and toxicological data across the NEBM lifecycle to perform adequate risk assessments and to ensure workplace health and safety.

【 授权许可】

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