Can ozone inactivate SARS-CoV-2? A review of mechanisms and performance on viruses

JOURNAL OF HAZARDOUS MATERIALS

卷:415

Review

Bayarri, Bernardi¹  Cruz-Alcalde, Alberto¹  Lopez-Vinent, Nuria¹  Mico, Maria M.¹  Sans, Carme¹ 

[1] Univ Barcelona, Dept Chem Engn & Analyt Chem, Fac Chem, C Marti & Franques 1, Barcelona 08028, Spain

关键词: SARS-CoV-2;    COVID-19;    Ozonation;    Aerosols;    Fomites;    Inactivation;    Enveloped viruses;   

DOI  :  10.1016/j.jhazmat.2021.125658

来源: Elsevier

【 摘 要 】

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has challenged societies around the globe. Technologies based on ozone, a powerful oxidant, have been evaluated to inactivate this virus in aerosols and fomites. However, the high data diversity hinders the possibility of establishing a common ground for determining best practices for the use of these technologies. Furthermore, there is a lack of consensus regarding which are the main mechanisms of ozone virus inactivation. This critical review examined the most relevant information available regarding ozone application in gas-phase for different viruses inactivation (including recent publications dealing with SARS-CoV-2), and pointed towards envelope alteration as the main reaction pathway for enveloped viruses, such as is the case of SARS-CoV-2. It could also be concluded that gaseous ozone can be indeed an effective disinfectant, successfully inactivating viruses such us influenza A H1N1, MERS-CoV, SARS-CoV-1 or even SARS-CoV-2 in aerosols or fomites. In reviewed works, low ozone exposures, just around 0.1-0.4 mg L-1 min, achieve about 4 log10 of inactivation in aerosols, while exposures between 1 and 4 mg L-1 min may be needed to guarantee an inactivation of 3-4 log10 in different fomites. Although further studies are required, ozone is an effective candidate to be used against SARS-CoV-2 or other viruses in surfaces and indoor locations.

【 授权许可】

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