High-throughput multi-residue quantification of contaminants of emerging concern in wastewaters enabled using direct injection liquid chromatography-tandem mass spectrometry

JOURNAL OF HAZARDOUS MATERIALS

卷:398

Article

Ng, Keng Tiong¹  Rapp-Wright, Helena^1,2,3  Egli, Melanie¹  Hartmann, Alicia^1,4  Steele, Joshua C.^5,9,11  Eduardo Sosa-Hernandez, Juan⁶  Melchor-Martinez, Elda M.⁶  Jacobs, Matthew^2,3  White, Blanaid^2,3  Regan, Fiona^2,3  Parra-Saldivar, Roberto⁶  Couchman, Lewis⁷  Halden, Rolf U.^5,9,10,11  Barron, Leon P.^1,8 

[1] Kings Coll London, Dept Analyt Environm & Forens Sci, 150 Stamford St, London SE1 9NH, England

[2] Dublin City Univ, DCU Water Inst, Dublin 9, Ireland

[3] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

[4] Hsch Fresenius, Limburger Str 2, Idstein, Hessen, Germany

[5] Arizona State Univ, Biodesign Inst, Biodesign Ctr Environm Hlth Engn, 1001 S McAllister Ave, Tempe, AZ 85287 USA

[6] Tecnol Monterrey, Escuela Ingn & Ciencias, Campus Monterrey,Ave Eugenio Garza Sada 2501, Monterrey 64849, Nuevo Leon, Mexico

[7] St Georges Univ London, Analyt Serv Int, London, England

[8] Imperial Coll London, Fac Med, Sch Publ Hlth, Environm Res Grp, London, England

[9] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ USA

[10] Arizona State Univ Fdn, OneWaterOneHlth, 1001 S McAllister Ave, Tempe, AZ 85287 USA

[11] AquaVitas LLC, 9260 E Raintree Dr,Ste 140, Scottsdale, AZ 85260 USA

关键词: Wastewater;    Direct injection LC-MS/MS;    Pharmaceuticals;    Illicit drugs;    Pesticides;   

DOI  :  10.1016/j.jhazmat.2020.122933

来源: Elsevier

【 摘 要 】

A rapid quantitative method for 135 contaminants of emerging concern (CECs) in untreated wastewater enabled with direct injection liquid chromatography-tandem mass spectrometry is presented. All compounds were analysed within 5 min on a short biphenyl cartridge using only 10 mu L of filtered sample per injection. Up to 76 compounds were monitored simultaneously during the gradient (including mostly two transitions per compound and stable isotope-labelled analogues) while yielding > 10 data points per peak. Evaluation of seven solid phase extraction sorbents showed no advantage for wastewater matrix removal. Excellent linearity, range, accuracy and precision was achieved for most compounds. Matrix effects were < 11 % and detection limits were < 30 ng L-1 on average. Application to untreated wastewater samples from three wastewater treatment works in the UK, USA and Mexico, enabled quantification of 56 compounds. Banned and EU 'watch-list' substances are critically discussed, including pesticides, macrolide antibiotics, diclofenac, illicit drugs as well as multiple pharmaceuticals and biocides. This high-throughput method sets a new standard for the speedy and confident determination of over a hundred CECs in wastewater at the part-per-trillion level, as demonstrated by performing over 260 injections per day.

【 授权许可】

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