Autophagosome-Lysosome Fusion

JOURNAL OF MOLECULAR BIOLOGY

卷:432

Review

Lorincz, Peter^1,2  Juhasz, Gabor^1,3 

[1] Eotvos Lorand Univ, Dept Anat Cell & Dev Biol, H-1117 Budapest, Hungary

[2] Hungarian Acad Sci, Premium Postdoctoral Res Program, Budapest, Hungary

[3] Hungarian Acad Sci, Biol Res Ctr, Inst Genet, H-6726 Szeged, Hungary

关键词: Autophagy;    Autophagosome;    Lysosome;    Fusion;    Vesicle tethering;   

DOI  :  10.1016/j.jmb.2019.10.028

来源: Elsevier

【 摘 要 】

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during which selected cellular components are transported to and broken down within lysosomes. The process starts with the capture of unnecessary material into autophagosomes, which is followed by autophagosome-lysosome fusion to generate autolysosomes that degrade the cargo. In the past quarter-century, our knowledge about autophagosome formation almost exponentially increased, while the later steps were much less studied. This fortunately changed in the past few years, with more and more publications focusing on the fate of the completed autophagosome. In this review, we aspire to summarize the current knowledge about the molecular mechanisms of autophagosome-lysosome fusion. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free