Autophagy: Principles and significance in health and disease

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1792

Review

Todde, Virginia¹  Veenhuis, Marten^1,2  van der Klei, Ida J.^1,2 

[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst GBB, NL-9750 AA Haren, Netherlands

[2] Kluyver Ctr Genom Ind Fermentat, NL-2628 BC Delft, Netherlands

关键词: Yeast;    Autophagy;    ATG genes;    Vacuole;    Lysosome;    Autophagosome;   

DOI  :  10.1016/j.bbadis.2008.10.016

来源: Elsevier

【 摘 要 】

Degradation processes are important for optimal functioning of eukaryotic cells. The two major protein degradation pathways in eukaryotes are the ubiquitin-proteasome pathway and autophagy. This contribution focuses on autophagy. This process is important for survival of cells during nitrogen starvation conditions but also has a house keeping function in removing exhausted, redundant or unwanted cellular components. We present an overview of the molecular mechanism involved in three major autophagy pathways: chaperone mediated autophagy, microautophagy and macroautophagy. Various recent reports indicate that autophagy plays a crucial role in human health and disease. Examples are presented of lysosomal storage diseases and the role of autophagy in cancer, neurodegenerative diseases, defense against pathogens and cell death. (C) 2008 Elsevier B.V. All rights reserved.

【 授权许可】

Free