Effectively communicating comprehensive tumor genomic profiling results: Mitigating uncertainty for advanced cancer patients

PATIENT EDUCATION AND COUNSELING

卷:105

Article

Bartley, Nicci¹  Best, Megan C.^1,2  Biesecker, Barbara B.³  Fisher, Alana¹  Goldstein, David⁴  Meiser, Bettina⁵  Thomas, David M.^6,7  Ballinger, Mandy L.^6,7  Butow, Phyllis¹ 

[1] Univ Sydney, Sch Psychol, Sydney, NSW, Australia

[2] Univ Notre Dame, Inst Eth & Soc, Sydney, NSW, Australia

[3] Res Triangle Inst, Bethesda, MD USA

[4] Univ NSW, Prince Wales Clin Sch, Sydney, NSW, Australia

[5] Univ NSW, Prince Wales Clin Sch, Psychosocial Res Grp, Sydney, NSW, Australia

[6] Garvan Inst Med Res, Canc Theme, Sydney, NSW, Australia

[7] Univ NSW, St Vincents Clin Sch, Sydney, NSW, Australia

关键词: Uncertainty;    Coping;    Comprehensive tumor profiling;    Genomics;    Oncology;   

DOI  :  10.1016/j.pec.2021.05.018

来源: Elsevier

【 摘 要 】

Objective: To understand advanced cancer patients' experience of uncertainty when receiving comprehensive tumor genomic profiling (CTGP) results, and their perceptions of how healthcare provider (HCP) communication impacts uncertainty. Methods: Thirty-seven semi-structured interviews with advanced cancer patients were conducted within two weeks of patients receiving CTGP results. Transcripts were thematically analyzed, using an inductive approach. Results: We identified three themes that illustrate patient experience of uncertainties when receiving CTGP results: 1. Type and degree of uncertainty fluctuates along with changing illness circumstances and the nature of the CTGP results; 2. HCPs' co-ordination of care and communication shapes uncertainty, with immediate, clearer and simpler information promoting certainty; and 3. Patients felt that communicating results to reduce relatives' uncertainty is important, with patients choosing the time and process for achieving this and desiring HCPs support. Conclusion: Oncology patients are confronted with an array of uncertainties. Clear, simple communication from HCPs about results and their implications, and support to manage uncertainty, will be of benefit. Practice implications: If CTGP is to become routine clinical practice, clear communication will be crucial in reducing uncertainty. Awareness of potential uncertainties experienced by patients when receiving results, will assist HCPs to address uncertainties, reduce uncertainty where possible, and offer targeted support to patients struggling with uncertainty. (c) 2021 Published by Elsevier B.V.

【 授权许可】

Free