Reconciling the different faces of hippocampal theta: The role of theta oscillations in cognitive, emotional and innate behaviors

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:85

Article; Proceedings Paper

Korotkova, Tatiana^1,2  Ponomarenko, Alexey¹  Monaghan, Caitlin K.^3,4  Poulter, Steven L.⁵  Cacucci, Francesca⁶  Wills, Tom⁷  Hasselmo, Michael E.^3,4  Lever, Colin⁵ 

[1] Leibniz Inst Mol Pharmacol FMP, Behav Neurodynam Grp, NeuroCure Cluster Excellence, CCO, Charitepl 1, D-10117 Berlin, Germany

[2] Max Planck Inst Metab Res, Neuronal Circuits & Behav Res Grp, Gleueler Str 50, D-50931 Cologne, Germany

[3] Boston Univ, Ctr Syst Neurosci, Dept Psychol & Brain Sci, 2 Cummington Mall, Boston, MA 02215 USA

[4] Boston Univ, Grad Program Neurosci, 2 Cummington Mall, Boston, MA 02215 USA

[5] Univ Durham, Dept Psychol, Durham DH1 3LE, England

[6] UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England

[7] UCL, Dept Cell & Dev Biol Physiol & Pharmacol, London WC1E 6BT, England

关键词: Hippocampus;    Entorhinal cortex;    Memory;    Resonance;    Grid cells;    Place cells;    Behaving mice;    Anxiety;    Speed;    Optogenetics;   

DOI  :  10.1016/j.neubiorev.2017.09.004

来源: Elsevier

【 摘 要 】

The theta oscillation (5-10 Hz) is a prominent behavior-specific brain rhythm. This review summarizes studies showing the multifaceted role of theta rhythm in cognitive functions, including spatial coding, time coding and memory, exploratory locomotion and anxiety-related behaviors. We describe how activity of hippocampal theta rhythm generators - medial septum, nucleus incertus and entorhinal cortex, links theta with specific behaviors. We review evidence for funtions of the theta-rhythmic signaling to subcortical targets, including lateral septtun. Further, we describe functional associations of theta oscillation properties - phase, frequency and amplitude - with memory, locomotion and anxiety, and outline how manipulations of these features, using optogenetics or pharmacology, affect associative and innate behaviors. We discuss work linking cognition to the slope of the theta frequency to running speed regression, and emotion-sensitivity (anxiolysis) to its y-intercept. Finally, we describe parallel emergence of theta oscillations, theta-mediated neuronal activity and behaviors during development. This review highlights a complex interplay of neuronal circuits and synchronization features, which enables an adaptive regulation of multiple behaviors by theta-rhythmic signaling.

【 授权许可】

Free