Age-related changes in the mesial temporal lobe: the parahippocampal white matter region

NEUROBIOLOGY OF AGING

卷:33

Article

Stoub, Travis R.¹  Barnes, Carol A.^2,3,4,5  Shah, Raj C.^6,7  Stebbins, Glenn T.¹  Ferrari, Carolyn¹  deToledo-Morrell, Leyla¹ 

[1] Rush Univ, Dept Neurol Sci, Med Ctr, Chicago, IL 60612 USA

[2] Univ Arizona, Dept Psychol, Tucson, AZ 85721 USA

[3] Univ Arizona, Dept Neurol, Tucson, AZ USA

[4] Univ Arizona, Arizona Res Labs, Div Neural Syst Memory & Aging, Tucson, AZ USA

[5] Univ Arizona, Evelyn F McKnight Brain Inst, Tucson, AZ USA

[6] Rush Univ, Dept Family Med, Med Ctr, Chicago, IL 60612 USA

[7] Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL 60612 USA

关键词: Imaging;    Aging;    Memory;    Hippocampus;    Entorhinal cortex;   

DOI  :  10.1016/j.neurobiolaging.2011.02.010

来源: Elsevier

【 摘 要 】

The perforant pathway originates from cells in the entorhinal cortex and relays sensory information from the neocortex to the hippocampus, a region critical for memory function. Imaging studies have demonstrated structural alterations in the parahippocampal white matter in the region of the perforant pathway in people at risk for developing Alzheimer's disease. It is not clear, however, if changes noted in this region are indicative of pathological aging or are a function of the normal aging process. We compared magnetic resonance imaging (MRI)-derived mesial temporal lobe volumes in 51 healthy older individuals and 40 young participants, with an emphasis on the parahippocampal white matter. Yearly clinical evaluations showed that 9 of the older cohort declined in cognitive function. Parahippocampal white matter, hippocampal, and entorhinal cortex volumes were significantly reduced in healthy older people who remained stable over time compared with young participants. These findings suggest that volume differences in mesial temporal lobe gray and white matter structures may take place as a result of the normative aging process. (C) 2012 Elsevier Inc. All rights reserved.

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