3T hippocampal glutamate-glutamine complex reflects verbal memory decline in aging

NEUROBIOLOGY OF AGING

卷:54

Article

Nikolova, Simona^1,2  Stark, Shauna M.^1,2  Stark, Craig E. L.^1,2 

[1] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA

[2] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92717 USA

关键词: 3T MRI;    Aging;    MRS;    Memory;    Imaging;    Glx;   

DOI  :  10.1016/j.neurobiolaging.2017.01.026

来源: Elsevier

【 摘 要 】

The hippocampus is a critical site for alterations that are responsible for age-related changes in memory. Here, we present a relatively novel approach of examining the relationship between memory performance and glutamate-glutamine levels using short echo time magnetic resonance spectroscopy. Specifically, we investigated the relationship between Glx (a composite of glutamate and glutamine) levels in the hippocampus, performance on a word-recall task, and resting-state functional connectivity. While there was no overall difference in Glx intensity between young and aging adults, we identified a positive correlation between delayed word-list recall and Glx, bilaterally in older adults, but not in young adults. Collapsed across age, we also discovered a negative relationship between Glx intensity and resting-state functional connectivity between the anterior hippocampus and regions in the subcallosal gyrus. These findings demonstrate the possible utility of Glx in identifying age-related changes in the brain and behavior and provide encouragement that magnetic resonance spectroscopy can be useful in predicting age-related decline before any physical abnormalities are present. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

Free