Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:72

Review

Zhang, Nan^1,2  Gordon, Marc L.^1,3  Goldberg, Terry E.^1,3 

[1] Feinstein Inst Med Res, Litwin Zucker Res Ctr, 350 Community Dr, Manhasset, NY 11030 USA

[2] Tianjin Med Univ, Dept Neurol, Gen Hosp, Tianjin Neurol Inst, Tianjin, Peoples R China

[3] Hofstra Northwell Sch Med, Hempstead, NY USA

关键词: Arterial spin labeling;    Magnetic resonance imaging;    Cerebral blood flow;    Aging;    Mild cognitive impairment;    Alzheimer's disease;   

DOI  :  10.1016/j.neubiorev.2016.11.023

来源: Elsevier

【 摘 要 】

Arterial spin labeling (ASL) magnetic resonance imaging uses arterial blood water as an endogenous tracer to measure cerebral blood flow (CBF). In this review, based on ASL studies in the resting state, we discuss state-of-the-art technical and data processing improvements in ASL, and ASL CBF changes in normal aging, mild cognitive impairment (MCI), Alzheimer's disease (AD), and other types of dementia. We propose that vascular and AD risk factors should be considered when evaluating CBF changes in aging, and that other validated biomarkers should be used as inclusion criteria or covariates when evaluating CBF changes in MCI and AD. With improvements in hardware and experimental design, ASL is proving to be an increasingly promising tool for exploring pathogenetic mechanisms, early detection, monitoring disease progression and pharmacological response, and differential diagnosis of AD. (C) 2016 The Authors. Published by Elsevier Ltd.

【 授权许可】

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