期刊论文详细信息
NEUROBIOLOGY OF AGING 卷:46
Mean arterial pressure change associated with cerebral blood flow in healthy older adults
Article
Deverdun, Jeremy1,2,3,4  Akbaraly, Tasnime N.5,6,7,8,9  Charroud, Celine3,10  Abdennour, Meriem10,11  Brickman, Adam M.12  Chemouny, Stephane2  Steffener, Jason12  Portet, Florence10,11,13  Bonafe, Alain3  Stern, Yaakov12  Ritchie, Karen10,11,14  Molino, Francois1,3,4  Le Bars, Emmanuelle3  de Champfleur, Nicolas Menjot3,15 
[1] Univ Montpellier 2, CNRS, Lab Charles Coulomb, UMR 5221, Montpellier, France
[2] Intrasense, Montpellier, Herault, France
[3] Univ Hosp Ctr, Gui de Chauliac Hosp, I2FH, Dept Neuroradiol, Montpellier, France
[4] Univ Montpellier I, Inst Genom Fonct, INSERM, UMR 5203,U661, Montpellier, France
[5] INSERM, U1198, Montpellier, France
[6] Univ Montpellier, Montpellier, France
[7] EPHE, Paris, France
[8] UCL, Dept Epidemiol & Publ Hlth, London, England
[9] INSERM, U710, Montpellier, France
[10] INSERM, U1061, Montpellier, France
[11] Univ Montpellier I, Montpellier, France
[12] Columbia Univ, Dept Neurol, Cognit Neurosci Div, New York, NY USA
[13] Montpellier Univ Hosp, Univ Dept Adult Psychiat, La Colombiere Hosp, Montpellier, France
[14] Imperial Coll, Fac Med, London, England
[15] St Eloi Hosp, Inst Neurosci Montpellier, Team Plast Cent Nervous Syst Stem Cells & Glial T, U1051, Montpellier, France
关键词: Cerebral blood flow;    Magnetic resonance imaging;    Aging;    Arterial spin labelling;    Hypertension;   
DOI  :  10.1016/j.neurobiolaging.2016.05.012
来源: Elsevier
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【 摘 要 】

We investigate over a 12-year period the association between regional cerebral blood flow (CBF) and cardiovascular risk factors in a prospective cohort of healthy older adults (81.96 +/- 3.82 year-old) from the Cognitive REServe and Clinical ENDOphenotype (CRESCENDO) study. Cardiovascular risk factors were measured over 12 years, and gray matter CBF was measured at the end of the study from high-resolution magnetic resonance imaging using arterial spin labeling. The association between cardiovascular risk factors, their long-term change, and CBF was assessed using multivariate linear regression models. Women were observed to have higher CBF than men (p < 0.05). Increased mean arterial pressure (MAP) over the 12-year period was correlated with a low cerebral blood flow (p < 0.05, R-2 = 0.21), whereas no association was detected between CBF and MAP at the time of imaging. High levels of glycemia tended to be associated with low cerebral blood flow values (p < 0.05). Age, alcohol consumption, smoking status, body mass index, history of cardiovascular disease, and hypertension were not associated with CBF. Our main result suggests that change in MAP is the most significant predictor of future CBF in older adults. (C) 2016 Elsevier Inc. All rights reserved.

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