Optimisation of pulsed and pseudo-continuous arterial spin labeling MRI techniques: A phantom study

10th International Seminar on Medical Physics; 1st AMDI International Oncology Symposium

物理学;医药卫生

Yusoff, Norain^1 ; Zukhi, Jihan^1 ; Rusli, Awatif^2 ; Zainon, Rafidah^1

Oncological and Radiological Sciences Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas, Pulau Pinang

13200, Malaysia^1

Hospital Seberang Jaya, Prai, Pulau Pinang, 13700, Malaysia^2

关键词: Arterial spin labeling;    Continuous arterial spin labeling;    Distilled water;    Imaging parameters;    Noninvasive technique;    Phantom studies;    Region of interest;    Slice thickness;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/851/1/012015/pdf
DOI  :  10.1088/1742-6596/851/1/012015

学科分类：卫生学

来源: IOP

【 摘 要 】

Arterial Spin Labeling (ASL) MRI is a non-invasive technique using a freely diffusible intrinsic tracer. The main objective of this study is to evaluate two different techniques of ASL MRI; pulsed ASL (PASL) and pseudo-continuous ASL (PCASL) in obtaining the best signal by manipulating the different imaging parameters. We used a fabricated Perspex flow phantom that is magnetically susceptible. The phantom has a straight tube that mimics carotid artery in adult patients and a U-shaped tube with 75% stenosis. We used a mixture of 60:40 distilled water and glycerol respectively as a substitute to blood. The fabricated phantom was scanned with 1.5T and 3T MRI Scanner using PCASL technique and PASL respectively. Two main imaging parameters were studied which were the field of view (FOV) and slice thickness (ST) to obtain the signal-to-noise ratio (SNR) of the region of interests. The 1.5 T PCASL technique gave SNR values of (13, 22, 30.1) for ST (5, 7, 9 mm) and FOV 240. When higher FOV = 320 was selected, the SNR values were (26.8, 15, 37) for different ST (5, 7, 9 mm). The 3.0 T PASL technique gave the SNR values of (9, 9.3, 11) for ST (5, 7, 9mm) and FOV 240mm. In the higher FOV = 320 mm, we obtained SNR values of (15.2, 17.5, 37.2) for ST (5, 7, 9 mm). As a conclusion, the images quality which can be measured by SNR value is affected by types of ASL and also different parameters.