Motor symptoms in Parkinson's disease: A unified framework

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:68

Review

Moustafa, Ahmed A.^1,2,3  Chakravarthy, Srinivasa⁴  Phillips, Joseph R.^2,3  Gupta, Ankur⁴  Keri, Szabolcs^5,6,7  Polner, Bertalan^5,6  Frank, Michael J.⁸  Jahanshahi, Madan^9,10 

[1] New Jersey Hlth Care Syst, Dept Vet Affairs, E Orange, NJ USA

[2] Univ Western Sydney, Sch Social Sci & Psychol, Sydney, NSW, Australia

[3] Univ Western Sydney, Marcs Inst Brain & Behav, Sydney, NSW, Australia

[4] Indian Inst Technol, Dept Biotechnol, Madras, Tamil Nadu, India

[5] Nyiro Gyula Hosp, Natl Inst Psychiat & Addict, Budapest, Hungary

[6] Budapest Univ Technol & Econ, Dept Cognit Sci, Budapest, Hungary

[7] Univ Szeged, Fac Med, Dept Physiol, Szeged, Hungary

[8] Brown Univ, Brown Inst Brain Sci, Dept Cognit Linguist Sci & Psychol Sci, Providence, RI 02912 USA

[9] Natl Hosp Neurol & Neurosurg London, UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, Cognit Motor Neurosci Grp, London, England

[10] Natl Hosp Neurol & Neurosurg London, UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, Unit Funct Neurosurg, London, England

关键词: Parkinson's disease;    Tremor;    Akinesia;    Bradykinesia;    Rigidly;    Freezing of gait;    Handwriting;    Grip force;    Speech;   

DOI  :  10.1016/j.neubiorev.2016.07.010

来源: Elsevier

【 摘 要 】

Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show additional motor deficits, including: gait disturbance, impaired handwriting, grip force and speech deficits, among others. Some of these motor symptoms (e.g., deficits of gait, speech, and handwriting) have similar clinical profiles, neural substrates, and respond similarly to dopaminergic medication and deep brain stimulation (DBS). Here, we provide an extensive review of the clinical characteristics and neural substrates of each of these motor symptoms, to highlight precisely how PD and its medical and surgical treatments impact motor symptoms. In conclusion, we offer a unified framework for understanding the range of motor symptoms in PD. We argue that various motor symptoms in PD reflect dysfunction of neural structures responsible for action selection, motor sequencing, and coordination and execution of movement. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free