Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: A systematic review and meta-analyses of animal studies

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:114

Review

Ramsteijn, A. S.¹  Van de Wijer, L.²  Rando, J.³  van Luijk, J.⁴  Homberg, J. R.³  Olivier, J. D. A.¹ 

[1] Univ Groningen, Groningen Inst Evolutionary Life Sci, Dept Neurobiol, Groningen, Netherlands

[2] Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Med Ctr, Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Dept Hlth Evidence, Med Ctr, SYRCLE, Nijmegen, Netherlands

关键词: Activity and exploration;    Animal studies;    Antidepressants;    Anxiety;    Behavior;    Developmental exposure;    Ingestive and reward behavior;    Learning and memory;    Meta-analysis;    Motoric behavior;    Offspring;    Pregnancy;    Reflex and pain sensitivity;    Selective serotonin reuptake inhibitors (SSRIs);    Sensory processing;    Sleep and circadian activity;    Social behavior;    Stress coping;    Systematic review;    Teratogenic effects;   

DOI  :  10.1016/j.neubiorev.2020.04.010

来源: Elsevier

【 摘 要 】

In the Western world, 2-5 % of pregnant women use selective serotonin reuptake inhibitor (SSRI) antidepressants. There is no consensus on the potential long-term neurodevelopmental outcomes of early SSRI exposure. Our aim was to determine whether there is an overall effect of perinatal SSRI exposure in animals on a spectrum of behavioral domains. After a comprehensive database search in PubMed, PsycINFO, and Web of Science, we included 99 publications. We performed nine meta-analyses and two qualitative syntheses corresponding to different behavioral categories, aggregating data from thousands of animals. We found evidence for reduced activity and exploration behavior (standardized mean difference (SMD) -0.28 [-0.38, -0.18]), more passive stress coping (SMD -0.37 -0.52, -0.23]), and less efficient sensory processing (SMD -0.37 -0.69, -0.06]) in SSRI- versus vehicle-exposed animals. No differences were found for anxiety (p = 0.06), social behavior, learning and memory, ingestive- and reward behavior, motoric behavior, or reflex and pain sensitivity. Exposure in the period equivalent to the human third trimester was associated with the strongest effects.

【 授权许可】

Free