Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:49

Review

Hirao, Kentaro^1,2  Pontone, Gregory M.¹  Smith, Gwenn S.¹ 

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA

[2] Tokyo Med Univ, Dept Geriatr Med, Tokyo 1608402, Japan

关键词: Positron emission tomography;    Molecular imaging;    Serotonin;    Dopamine;    Acetylcholine;    Alzheimer's disease;    Parkinson's disease;    Neuropsychiatric symptoms;   

DOI  :  10.1016/j.neubiorev.2014.11.010

来源: Elsevier

【 摘 要 】

Neuropsychiatric symptoms (NPS) are very common in neurodegenerative diseases and are a major contributor to disability and caregiver burden. There is accumulating evidence that NPS may be a prodrome and/or a risk factor of neurodegenerative diseases. The medications used to treat these symptoms in younger patients are not very effective in patients with neurodegenerative disease and may have serious side effects. An understanding of the neurobiology of NPS is critical for the development Of more effective intervention strategies. Targeting these symptoms may also have implications for prevention of cognitive or motor decline. Molecular brain imaging represents a bridge between basic and clinical observations and provides many opportunities for translation from animal models and human post-mortem studies to in vivo human studies. Molecular brain imaging studies in Alzheimer's disease (AD) and Parkinson's disease (PD) are reviewed with a primary focus on positron emission tomography studies of NPS. Future directions for the field of molecular imaging in AD and PD to understand the neurobiology of NPS will be discussed. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free