Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:121

Review

Mimura, Yu¹  Nishida, Hana¹  Nakajima, Shinichiro^1,2  Tsugawa, Sakiko¹  Morita, Shinji¹  Yoshida, Kazunari^1,3  Tarumi, Ryosuke¹  Ogyu, Kamiyu¹  Wada, Masataka¹  Kurose, Shin¹  Miyazaki, Takahiro¹  Blumberger, Daniel M.^4,5  Daskalakis, Zafiris J.^4,5  Chen, Robert⁶  Mimura, Masaru¹  Noda, Yoshihiro¹ 

[1] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan

[2] Univ Toronto, Multimodal Imaging Grp, Res Imaging Ctr, Ctr Addict & Mental Hlth, Toronto, ON, Canada

[3] Ctr Addict & Mental Hlth, Pharmacogenet Res Clin, Toronto, ON, Canada

[4] Ctr Addict & Mental Hlth, Temerty Ctr Therapeut Brain Intervent, Toronto, ON, Canada

[5] Univ Toronto, Dept Psychiat, Fac Med, Toronto, ON, Canada

[6] Univ Toronto, Univ Hlth Network, Krembil Res Inst, Div Neurol,Dept Med,Div Brain Imaging & Behav Sys, Toronto, ON, Canada

关键词: Alzheimer's disease;    Mild cognitive impairment;    RMT;    SAI;    SICI;    ICF;    LICI;    Plasticity;    PAS;    TMS;    Biomarker;   

DOI  :  10.1016/j.neubiorev.2020.12.003

来源: Elsevier

【 摘 要 】

Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological tool that enables the investigation of cortical excitability in the human brain. Paired-pulse TMS paradigms include shortand long-interval intracortical inhibition (SICI/LICI), intracortical facilitation (ICF), and short-latency afferent inhibition (SAI), which can assess neurophysiological functions of GABAergic, glutamatergic, and cholinergic neural circuits, respectively. We conducted the first systematic review and meta-analysis to compare these TMS indices among patients with AD, mild cognitive impairment (MCI), and healthy controls (HC). Our meta-analyses indicated that RMT, SAI, SICI, and LICI were significantly lower in patients with AD, while ICF did not show a difference in patients with AD compared with HC. In patients with MCI, RMT and SAI were significantly lower than in HC. In conclusion, motor cortical excitability was increased, while cholinergic function was decreased in AD and MCI in comparison with HC and patients with AD had decreased GABAergic and glutamatergic functions compared with HC. Our results warrant further studies to differentiate AD, MCI, and HC, employing multimodal TMS neurophysiology.

【 授权许可】

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