Neural substrates of appetitive and aversive prediction error

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:123

Article

Iordanova, Mihaela D.¹  Yau, Joanna Oi-Yue²  McDannald, Michael A.³  Corbit, Laura H.^4,5 

[1] Concordia Univ, Ctr Studies Behav Neurobiol, Dept Psychol, 7141 Sherbrooke St, Montreal, PQ H4B 1R6, Canada

[2] Univ New South Wales, UNSW Sydney, Sch Psychol, Sydney, NSW 2052, Australia

[3] Boston Coll, Dept Psychol & Neurosci, 140 Commonwealth Ave,514 McGuinn Hall, Chestnut Hill, MA 02467 USA

[4] Univ Toronto, Dept Psychol, 100 St George St, Toronto, ON M5S 3G3, Canada

[5] Univ Toronto, Dept Cell & Syst Biol, 100 St George St, Toronto, ON M5S 3G3, Canada

关键词: Reward;    Fear;    Learning;    Attention;    Noradrenaline;    Amygdala;    Dopamine;    Periaqueductal gray;    Opioids;   

DOI  :  10.1016/j.neubiorev.2020.10.029

来源: Elsevier

【 摘 要 】

Prediction error, defined by the discrepancy between real and expected outcomes, lies at the core of associative learning. Behavioural investigations have provided evidence that prediction error upand down-regulates associative relationships, and allocates attention to stimuli to enable learning. These behavioural advances have recently been followed by investigations into the neurobiological substrates of prediction error. In the present paper, we review neuroscience data obtained using causal and recording neural methods from a variety of key behavioural designs. We explore the neurobiology of both appetitive (reward) and aversive (fear) prediction error with a focus on the mesolimbic dopamine system, the amygdala, ventrolateral periaqueductal gray, hippocampus, cortex and locus coeruleus noradrenaline. New questions and avenues for research are considered.

【 授权许可】

Free