Social dysfunction after pediatric traumatic brain injury: A translational perspective

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:64

Review

Ryan, Nicholas P.^1,2  Catroppa, Cathy^1,2,3  Godfrey, Celia¹  Noble-Haeusslein, Linda J.^4,5  Shultz, Sandy R.⁶  O'Brien, Terence J.⁶  Anderson, Vicki^1,2,3  Semple, Bridgette D.⁶ 

[1] Murdoch Childrens Res Inst, Australian Ctr Child Neuropsychol Studies, Parkville, Vic, Australia

[2] Univ Melbourne, Melbourne Sch Psychol Sci, Fac Med Dent & Hlth Sci, Parkville, Vic 3052, Australia

[3] Royal Childrens Hosp, Dept Psychol, Flemington Rd, Parkville, Vic 3052, Australia

[4] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA

[5] Univ Calif San Francisco, Dept Phys Therapy & Rehabil Sci, San Francisco, CA 94143 USA

[6] Univ Melbourne, Dept Med, Royal Melbourne Hosp, Parkville, Vic 3052, Australia

关键词: Pediatric;    Traumatic brain injury;    Social interactions;    Social competency;    Communication;    Children;    Brain;    Behavior;    Social brain network;    Rodents;    Humans;   

DOI  :  10.1016/j.neubiorev.2016.02.020

来源: Elsevier

【 摘 要 】

Social dysfunction is common after traumatic brain injury (TBI), contributing to reduced quality of life for survivors. Factors which influence the development or persistence of social deficits after injury remain poorly understood, particularly in the context of ongoing brain maturation during childhood and adolescence. Aberrant social interactions have recently been modeled in adult and juvenile rodents after experimental TBI, providing an opportunity to gain new insights into the underlying neurobiology of these behaviors. Here, we review our current understanding of social dysfunction in both humans and rodent models of TBI, with a focus on brain injuries acquired during early development. Modulators of social outcomes are discussed, including injury-related and environmental risk and resilience factors. Disruption of social brain network connectivity and aberrant neuroendocrine function are identified as potential mechanisms of social impairments after pediatric TBI. Throughout, we highlight the overlap and disparities between outcome measures and findings from clinical and experimental approaches, and explore the translational potential of future research to prevent or ameliorate social dysfunction after childhood TBI. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free