Anxiety and Alzheimer's disease: Behavioral analysis and neural basis in rodent models of Alzheimer's-related neuropathology

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:127

Review

Pentkowski, Nathan S.¹  Rogge-Obando, Kimberly K.¹  Donaldson, Tia N.¹  Bouquin, Samuel J.¹  Clark, Benjamin J.¹ 

[1] Univ New Mexico, Dept Psychol, Albuquerque, NM 87109 USA

关键词: Alzheimer's disease;    Anxiety;    Open field;    Elevated plus-maze;    light/dark test;    Stress;    Ventral hippocampus;   

DOI  :  10.1016/j.neubiorev.2021.05.005

来源: Elsevier

【 摘 要 】

Alzheimer's disease (AD) pathology is commonly associated with cognitive decline but is also composed of neuropsychiatric symptoms including psychological distress and alterations in mood, including anxiety and depression. Emotional dysfunction in AD is frequently modeled using tests of anxiety-like behavior in transgenic rodents. These tests often include the elevated plus-maze, light/dark test and open field test. In this review, we describe prototypical behavioral paradigms used to examine emotional dysfunction in transgenic models of AD, specifically anxiety-like behavior. Next, we summarize the results of studies examining anxiety-like behavior in transgenic rodents, noting that the behavioral outcomes using these paradigms have produced inconsistent results. We suggest that future research will benefit from using a battery of tests to examine emotional behavior in transgenic AD models. We conclude by discussing putative, overlapping neurobiological mechanisms underlying AD-related neuropathology, stress and anxiety-like behavior reported in AD models.

【 授权许可】

Free