Neural correlates of emotional processing in psychosis risk and onset-A systematic review and meta-analysis of fMRI studies

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:128

Review

Lukow, P. B.¹  Kiemes, A.¹  Kempton, M. J.¹  Turkheimer, F. E.²  McGuire, P.¹  Modinos, G.^1,2,3 

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, De Crespigny Pk, London SE5 8AF, England

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, De Crespigny Pk, London SE5 8AF, England

[3] Kings Coll London, MRC Ctr Neurodev Disorders, New Hunts House,Guys Campus, London SE1 1UL, England

关键词: Emotion;    Psychosis;    Clinical high-risk;    Functional magnetic resonance imaging;    Seed-based d mapping;   

DOI  :  10.1016/j.neubiorev.2021.03.010

来源: Elsevier

【 摘 要 】

Aberrant emotion processing is a well-established component of psychotic disorders and is already present at the first episode of psychosis (FEP). However, the role of emotion processing abnormalities in the emergence of psychosis and the underlying neurobiology remain unclear. Here, we systematically reviewed functional magnetic resonance studies that used emotion processing task paradigms in FEP patients, and in people at clinical high-risk for psychosis (CHRp). Image-based meta-analyses with Seed-based d Mapping on available studies (n = 6) were also performed. Compared to controls, FEP patients showed decreased neural responses to emotion, particularly in the amygdala and anterior cingulate cortex. There were no significant differences between CHRp subjects and controls, but a high degree of heterogeneity was identified across studies. The role of altered emotion processing in the early phase of psychosis may be clarified through more homogenous experimental designs, particularly in the CHRp population.

【 授权许可】

Free