Research on spontaneous activity in adult anisometropic amblyopia with regional homogeneity

4th International Conference on Advanced Composite Materials and Manufacturing Engineering 2017

材料科学;化学

Huang, Yufeng^1 ; Zhou, Yifeng^1

Center of Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, ANHUI

230027, China^1

关键词: Functional magnetic resonance imaging;    Regional homogeneity;    Resting-state fmri;    Spontaneous activity;    Two sample t tests;    Vision information;    Visual impairment;    Visuomotor coordination;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/207/1/012008/pdf
DOI  :  10.1088/1757-899X/207/1/012008

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Amblyopia usually occurs in early childhood and results in monocular visual impairment. The functional magnetic resonance imaging (fMRI) studies have reflected functional anomaly in amblyopia. In resting-state fMRI study, spontaneous activity changes abnormally in anisometropic amblyopia could be revealed by the regional homogeneity (ReHo). Twenty two adult anisometropic amblyopes and Twenty one normal controls participated in this fMRI study. Two sample T test was carried out to analysis ReHo within the whole brain for the inter groups. Compare with normal group, our study found that the amblyopia's ReHo mainly increased in the left frontal lobe, while decreased in the left cerebellum, the temporal lobe (left and right), and the left parietal lobe. And the ReHo values in middle and inferior temporal lobe, the prefrontal lobe, frontal lobe (positive) and parietal lobe and medial frontal gyrus (negative) could be correlated with the acuity deficit of amblyopia. The results increased in ReHo may indicate compensatory plasticity in higher vision information process, while the decreased in ReHo may reflect decreased ability in eye movement, spatial sense and visuo-motor coordination. The correlation revealed that the vision deficit may correspond to the spontaneous in certain brain area.