Reduced resting-state brain activity in the default mode network in children with (central) auditory processing disorders

Behavioral and Brain Functions

Agnieszka Pluta¹  Tomasz Wolak¹  Natalia Czajka¹  Monika Lewandowska¹  Katarzyna Cieśla¹  Mateusz Rusiniak¹  Diana Grudzień¹  Henryk Skarżyński¹ 

[1] World Hearing Center of the Institute of Physiology and Pathology of Hearing, Mokra 17 street, 05-830 Nadarzyn, Warsaw/Kajetany, Poland

关键词: Central auditory processing disorders;    Functional magnetic resonance imaging;    Regional homogeneity;    Independent component analysis;    Default mode network;   

Others  :  1083998
DOI  :  10.1186/1744-9081-10-33

 received in 2014-01-28, accepted in 2014-09-15,  发布年份 2014

【 摘 要 】

Background

In recent years, there has been a growing interest in Central Auditory Processing Disorder (C)APD. However, the neural correlates of (C)APD are poorly understood. Previous neuroimaging experiments have shown changes in the intrinsic activity of the brain in various cognitive deficits and brain disorders. The present study investigated the spontaneous brain activity in (C)APD subjects with resting-state fMRI (rs-fMRI).

Methods

Thirteen children diagnosed with (C)APD and fifteen age and gender-matched controls participated in a rs-fMRI study during which they were asked to relax keeping their eyes open. Two different techniques of the rs-fMRI data analysis were used: Regional Homogeneity (ReHo) and Independent Component Analysis (ICA), which approach is rare.

Results

Both methods of data analysis showed comparable results in the pattern of DMN activity within groups. Additionally, ReHo analysis revealed increased co-activation of the superior frontal gyrus, the posterior cingulate cortex/the precuneus in controls, compared to the (C)APD group. ICA yielded inconsistent results across groups.

Conclusions

Our ReHo results suggest that (C)APD children seem to present reduced regional homogeneity in brain regions considered a part of the default mode network (DMN). These findings might contribute to a better understanding of neural mechanisms of (C)APD.

【 授权许可】

   
2014 Pluta et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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