Resting-state fMRI study of patients with fragile X syndrome

3rd International Conference and Young Scientist School "Magnetic resonance imaging in biomedical research"

物理学;医药卫生

Isanova, E.^1 ; Petrovskiy, E.^3 ; Savelov, A.^2,3 ; Yudkin, D.^1,2 ; Tulupov, A.^1,2,3

Institute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, Russia^1

Institute of Molecular and Cellular Biology, Russian Academy of Sciences, Novosibirsk, Russia^2

Institute International Tomography Centre, Russian Academy of Sciences, Russia^3

关键词: Basal activities;    Brain functions;    Default-mode networks;    Healthy volunteers;    Resting state functional connectivities;    Resting-state fmri;    Resting-state functional magnetic resonance imaging;    Statistically significant difference;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/886/1/012007/pdf
DOI  :  10.1088/1742-6596/886/1/012007

学科分类：卫生学

来源: IOP

【 摘 要 】

The study aimed to assess the neural activity of different brain regions in patients with fragile X syndrome (FXS) and the healthy volunteers by resting-state functional magnetic resonance imaging (fMRI) on a 1.5 T MRI Achieva scanner (Philips). Results: The fMRI study showed a DMN of brain function in patients with FXS, as well as in the healthy volunteers. Furthermore, it was found that a default mode network of the brain in patients with FXS and healthy volunteers does not have statistically significant differences (p>0.05), which may indicate that the basal activity of neurons in patients with FXS is not reduced. In addition, we have found a significant (p