Depression: An actionable outcome for those at clinical high-risk

SCHIZOPHRENIA RESEARCH

卷:227

Article

Addington, Jean¹  Farris, Megan S.¹  Liu, Lu¹  Cadenhead, Kristin S.²  Cannon, Tyrone D.³  Cornblatt, Barbara A.⁴  McGlashan, Thomas H.⁵  Perkins, Diana O.⁶  Seidman, Larry J.^7,8  Tsuang, Ming T.²  Walker, Elaine F.⁹  Bearden, Carrie E.^10,11,12  Mathalon, Daniel H.¹³  Stone, William S.^7,8  Keshevan, Matcheri^7,8  Woods, Scott W.⁵ 

[1] Univ Calgary, Hotchkiss Brain Inst, Dept Psychiat, Calgary, AB, Canada

[2] UCSD, Dept Psychiat, La Jolla, CA USA

[3] Yale Univ, Dept Psychol, New Haven, CT USA

[4] Zucker Hillside Hosp, Dept Psychiat, Long Isl City, NY USA

[5] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[6] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA

[7] Harvard Med Sch, Dept Psychiat, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[8] Massachusetts Gen Hosp, Boston, MA 02114 USA

[9] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[10] Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA

[11] Univ Calif Los Angeles, Dept Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA

[12] Univ Calif Los Angeles, Dept Psychol, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA

[13] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

关键词: Depression;    Clinical high-risk;    Psychosis;    Prognosis;    Symptoms;   

DOI  :  10.1016/j.schres.2020.10.001

来源: Elsevier

【 摘 要 】

Comorbid diagnoses are common in youth who are at clinical high-risk (CHR) for developing psychosis, with depression being the most common. The aim of this paper is to examine depression over two years in a large sample of CHR youth who do not make the transition to psychosis, considering both categorical and dimensional ratings of depression severity. The sample consisted of 267 CHR youth who were followed for two years. Based on DSM-IV diagnoses over this time period, 100 CHR individuals never received a diagnosis of depression, 64 individuals continuously met criteria for depression, 92 individuals received a diagnosis of depression at one or more timepoints, and 11 participants had a diagnosis of depression only at 24-months. These groupings were supported by six-monthly ratings on the Calgary Depression Scale. The majority of this sample experienced a major depressive episode on more than one occasion, suggesting that depression and depressive symptoms identify a domain of substantial unmet clinical need. Recommendations are that depression in CHR youth and young adults should be monitored more frequently and that there is a need for clinical trials to address depression systematically in this vulnerable population. (C) 2020 Elsevier B.V. All rights reserved.

【 授权许可】

Free